%0 Journal Article
%T Avapritinib: preclinical studies of a promising novel therapeutic option for gastrointestinal stromal tumors
%A Urbini, Milena
%J Gastrointestinal Stromal Tumor
%D 2019
%B 2019
%9 
%! Avapritinib: preclinical studies of a promising novel therapeutic option for gastrointestinal stromal tumors
%K 
%X Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor of the gastrointestinal tract (80%), with an annual incidence of 10–15 cases per million people (1). GISTs have become a paradigm for the use of molecular diagnostics and targeted therapy, since its molecular classification is able to predict treatment response. Most GISTs are driven by activating mutations in KIT (70–80% of cases) or PDGFRA (10%) receptor tyrosine kinases. This discovery represents the rationale of the efficacy of target therapies efficacy using small molecule tyrosine kinase inhibitors (TKIs) for this malignancy (1,2).
%U https://gist.amegroups.org/article/view/27016
%V 2
%P 
%@ 2663-1911